Systems and methods for automated detection of application vulnerabilities

*/Board of Regents, University of Texas Syste

Moral Imagination: The Missing Component in Global Health

Benatar explores the underlying reasons for our failure to make adequate progress in improving global health

Establishment of M1 multipolarity of a 6.5 mu_N^2 resonance in 172-Yb at E_gamma=3.3 MeV

Two-step-cascade spectra in 172-Yb have been measured after thermal neutron capture. They are compared to calculations based on experimental values of the level density and radiative strength function (RSF) obtained from the 173-Yb(3-He,alpha gamma)172-Yb reaction. The multipolarity of a 6.5(15) mu_N^2 resonance at E_gamma=3.3(1) MeV in the RSF is determined to be M1 by this comparison.Comment: 4 pages including 3 figure

Failures in transport infrastructure embankments

To ensure that road and rail transport networks remain operational, both highway and railway embankments require continual maintenance and renewal to mitigate against ongoing deterioration and repair any sections damaged by realised failures. This paper provides a review of recent developments in the understanding of highway and railway embankment degradation and failure. Failures due to pore water pressure increase, seasonal shrink-swell deformation and progressive failure are considered. The material composition and construction of highway and railway embankments differ, which influences the dominant type and timing of embankment failure. There is evidence for highway embankment failures induced by pore water pressure increase, but not seasonal deformation and progressive failure. Some railway embankments are susceptible to pore water pressure increase, seasonal shrink-swell deformation and progressive failure due to the age and nature of the dumped clay fill used in their construction. The approaches used to measure and explore embankment failure mechanisms are compared and discussed. Field observations have been used to understand pore water pressure increase and seasonal shrink-swell deformation in embankments, while the investigation of progressive embankment failure has mainly utilised physical and numerical modelling approaches. Further field and laboratory investigation is required before the rigorous analysis of embankment failure can be routinely undertaken. However, progress is being made to empirically identify and evaluate the various risk factors affecting transport infrastructure embankment failure

Infection of the malaria mosquito, Anopheles gambiae, with two species of entomopathogenic fungi: effects of concentration, co-formulation, exposure time and persistence

<p>Abstract</p> <p>Background</p> <p>Entomopathogenic fungi <it>Metarhizium anisopliae </it>and <it>Beauveria bassiana </it>isolates have been shown to infect and reduce the survival of mosquito vectors.</p> <p>Methods</p> <p>Here four different bioassays were conducted to study the effect of conidia concentration, co-formulation, exposure time and persistence of the isolates <it>M. anisopliae </it>ICIPE-30 and <it>B. bassiana </it>I93-925 on infection and survival rates of female <it>Anopheles gambiae sensu stricto</it>. Test concentrations and exposure times ranged between 1 × 10⁷- 4 × 10¹⁰conidia m^-2and 15 min - 6 h. In co-formulations, 2 × 10¹⁰conidia m^-2of both fungus isolates were mixed at ratios of 4:1, 2:1, 1:1,1:0, 0:1, 1:2 and 1:4. To determine persistence, mosquitoes were exposed to surfaces treated 1, 14 or 28 d previously, with conidia concentrations of 2 × 10⁹, 2 × 10¹⁰or 4 × 10¹⁰.</p> <p>Results</p> <p>Mosquito survival varied with conidia concentration; 2 × 10¹⁰conidia m^-2was the concentration above which no further reductions in survival were detectable for both isolates of fungus. The survival of mosquitoes exposed to single and co-formulated treatments was similar and no synergistic or additive effects were observed. Mosquitoes were infected within 30 min and longer exposure times did not result in a more rapid killing effect. Fifteen min exposure still achieved considerable mortality rates (100% mortality by 14 d) of mosquitoes, but at lower speed than with 30 min exposure (100% mortality by 9 d). Conidia remained infective up to 28 d post-application but higher concentrations did not increase persistence.</p> <p>Conclusion</p> <p>Both fungus isolates are effective and persistent at low concentrations and short exposure times.</p

Observations of vertical mixing in autumn and its effect on the autumn phytoplankton bloom

This work examines the seasonal cycle of density structure and its influence on primary production in a temperate shelf sea, with a particular focus on the breakdown of stratification in autumn. We do this by combining new, high resolution observations of water column structure, meteorological forcing, nitrate and chlorophyll fluorescence collected between March 2014 and July 2015 on the North West European Shelf. Our results challenge the generally accepted assumption that convection dominates over wind driven mixing resulting in seasonal breakdown of stratification. Furthermore we found, that vertical mixing in autumn not only transformed the vertical density structure but also the vertical structure of chlorophyll biomass and surface nutrients. The subsurface chlorophyll maximum was eroded and a vertically homogeneous profile of chlorophyll biomass established itself above the pycnocline. This increased mixing also led to replenishment of surface nitrate concentrations, which supported an autumn phytoplankton bloom. While the significance of phytoplankton blooms in autumn has previously not been well quantified, we argue that these can act as a significant contributor to the seasonal drawdown of carbon

A comprehensive survey of the analytical, numerical and experimental methodologies for dynamics of multibody mechanical systems with clearance or imperfect joints

"Available online 19 December 2017"A comprehensive survey of the literature of the most relevant analytical, numerical, and experimental approaches for the kinematic and dynamic analyses of multibody mechanical systems with clearance joints is presented in this review. Both dry and lubricated clearance joints are addressed here, and an effort is made to include a large number of research works in this particular field, which have been published since the 1960′s. First, the most frequently utilized methods for modeling planar and spatial multibody mechanical systems with clearance joints are analyzed, and compared. Other important phenomena commonly associated with clearance joint models, such as wear, non-smooth behavior, optimization and control, chaos, and uncertainty and links’ flexibility, are then discussed. The main assumptions procedures and conclusions for the different methodologies are also examined and compared. Finally, future developments and new applications of clearance joint modeling and analysis are highlighted.This research was supported in part by the China 111 Project (B16003) and the National Natural Science Foundation of China under Grants 11290151, 11472042 and 11221202. The work was also supported by the Portuguese Foundation for Science and Technology with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941.info:eu-repo/semantics/publishedVersio

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine